Technology

ClarityCapture™

A oligonucleotide purification technology that replaces traditional chromatography with a fast, high purity membrane capture.

Compatible with standard phosphoramidite synthesis workflows.

Superior purity for long or modified oligos vs. DMT-on purification.

Over 20x faster purification than HPLC/FPLC.

Resin and solvent free — no column packing or solvent waste.

Linearly scalable from bench to clinic with consistent purity.

How it works

Incorporate our ClarityCapture™ Amidite as the final base during synthesis.

After cleavage and deprotection, add our ClarityCapture™ Tag and bind to the membrane column.

Wash away coupling failure impurities.

Cleave the ClarityCapture™ Tag, release the purified oligonucleotide and proceed with lyophilization or downstream conjugation.

Integrate ClarityCapture™ directly into your existing phosphoramidite synthesis workflow. Everything you need to get started, in one kit.

Easy workflow integration

Includes phosphoramidite, tag and membrane column

Available in 96-well plate or single column packs

Send us your sequence. Receive purified oligos demonstrating what ClarityCapture™ can deliver for your application.

1 mg test batch for your sequences

Turnaround and pricing on request based on 5' modification

Full QC including HPLC and LCMS purity assessment